Born in 1919. His parents were the Yiddish actors Chana Lerner and David Zayderman. He was raised in Berlin, Germany by family. He completed the gymnasium and studied as a medical doctor, but due to the Hitler regime he had to interrupt his studies, and together with his parents went away to Poland, to Warsaw, where they were then put into the ghetto He had never thought about acting in theatre, but the changed living conditions had also moreover gefirt.

Jonas Turkow writes about this:

"Suddenly he was deported for a non-average-ability actor. Harry Zayderman was a pest-born student (with a head above his father), with a beautiful, bright face, a beautiful pronunciation, and a very large stage ability.

He didn't have his father's voice, but he exceeded him in acting talent.

His parents was very welcoming and proud of him, and they actually had a right. David Zayderman was a big joker, and in this connection did not omit the opportunity to say: 'From my big vocals and Chana's (his wife Chana Lerner) great soubrette-like temperament, there came into the world a great dramatic talent. "To gey, zay a khokhem."